A NEW PROCESS FOR PREPARATION OF ATOVAQUONE AND NOVEL INTERMEDIATES THEREOF

摘要

Disclosed herein is novel process for preparation of Atovaquone, which process includes reacting 1,4-naphthoquinone with trans-4-(4-chlorophenyl) cyclohexane carboxylic acid followed by halogenation to obtain dihalo-compound, further dehydrohalogenation of dihalo- compound to obtain monohalogeno-compound, and hydrolysis of the monohalogeno - compound to obtain Atovaquone. The invention further discloses Atovaquone in a substantially pure and well defined polymorphic form designated as "Form IPCA-ATO", and the preparation thereof.