发明名称 |
RS1 DEFIZIENTES TRANSGENES TIER UND DESSEN VERWENDUNGEN |
摘要 |
Described is a transgenic non-human RS1-/- animal characterized in that it shows increased body weight, increased total fat and/or increased mean fat cell volume compared to a wild type animal. Also described are various uses of said animal, e.g. as an animal model for adipositas or hypercholesterolaemia, for identifying substances suitable for the therapy and/or prevention of adipositas or hypercholesterolaemia or for assaying the efficacy of dieting or pharmacological therapy of adipositas or hypercholesterolaemia. Finally, the use of compounds is described which are capable of modulating the activity/expression of RS1 for the treatment or prevention of diseases like adipositas or hypercholesterolaemia. |
申请公布号 |
AT419747(T) |
申请公布日期 |
2009.01.15 |
申请号 |
AT20030002465T |
申请日期 |
2003.02.05 |
申请人 |
KOEPSELL, HERMANN |
发明人 |
KOEPSELL, HERMANN;LANG, FLORIAN;OSSWALD, CHRISTINA |
分类号 |
A01K67/027;A61K38/00;A61K38/17;A61K48/00;C07K14/47;C12N15/85;C12Q1/68;G01N33/50;G01N33/53 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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