DIPHENHYDRAMINE-ACESULFAME ADDUCT, METHOD FOR PRODUCING THE SAME AND ORAL PREPARATION CONTAINING THE ADDUCT

摘要

PROBLEM TO BE SOLVED: To obtain a new diphenhydramine derivative that has a pharmacological activity as an antihistaminic agent and a sleep-introducing agent and alleviated bitterness; to provide a method for producing the same; and to obtain an oral preparation composed of the diphenhydramine derivative as an active ingredient. SOLUTION: The diphenhydramine-acesulfame adduct has a structure represented by formula (I). The method for producing the adduct includes bringing a diphenhydramine cation-containing water-soluble salt into contact with an acesulfame anion-containing water-soluble salt in a water-based medium. The oral preparation contains the adduct. COPYRIGHT: (C)2009,JPO&INPIT