MINOR SPLICOSOME ASSAY SYSTEM FOR MODULATING CELL DIVISION

摘要

Assay system for the inhibitory or activating modulation of the cell division in eukaryotes comprising at least one cellular in-vivo system comprising at least one spliceable pre-mRNA which comprises at least one intron and whose splicing is dependent on at least one snRNA U12 or U11 or U6atac or U5 or U4atac and the pre-mRNA comprises, in (a), at least one splicing site for U12 or U11, in the presence of at least one substance of interest, and a detectable signal is induced, if appropriate together with further auxiliaries.