| 发明名称 |
High affinity TGFß nucleic acid ligands and inhibitors |
| 摘要 |
Methods are described for the identification and preparation of high-affinity nucleic acid ligands to TG²2. Included in the invention are specific RNA ligands to TGF²2 identified by the SELEX method. Also included are RNA ligands that inhibit the interaction of TGF²2 with its receptor. |
| 申请公布号 |
EP1975172(A3) |
申请公布日期 |
2009.01.14 |
| 申请号 |
EP20080007004 |
申请日期 |
2000.07.26 |
| 申请人 |
GILEAD SCIENCES, INC. |
发明人 |
PAGRATIS, NIKOS;LOCHRIE, MICHAEL;GOLD, LARRY |
| 分类号 |
C07H21/02;C12N15/09;A61K9/127;A61K38/00;A61K47/48;A61P25/00;A61P31/00;A61P35/00;A61P35/04;A61P37/02;A61P43/00;C07B61/00;C07H19/06;C07H19/10;C07H21/00;C07H21/04;C07K14/00;C07K14/49;C07K14/495;C07K14/50;C12N9/12;C12N15/10;C12N15/113;C12N15/115;C12Q1/37;C12Q1/68;C12Q1/70;F02B75/02;G01N33/531;G01N33/532;G01N33/535;G01N33/569;G01N33/68;G01N33/76 |
主分类号 |
C07H21/02 |
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