PROCESS TO INCREASE THE PRODUCTION OF CLAVAM ANTIBIOTICS

摘要

A process for increasing the amount of clavam produced by an organism having both a clavam pathway or a portion thereof and a cephalosporin pathwa y or a portion thereof by interfering with the conversion of L-lysine to L- .alpha.- aminoadipic acid in the cephalosporin pathway. Plasmids containing a defecti ve LAT (lysine amino transferase) gene and organisms containing such plasmids are also provided.