发明名称 |
Injectable methadone, methadone and naltrexone, or buprenorphine and naltrexone microparticle compositions and their use in reducing consumption of abused substances |
摘要 |
An injectable slow-release methadone, partial opioid agonist or opioid antagonist formulation is provided comprising methadone, a partial opioid agonist or opioid antagonist in a poly(D,L-lactide) excipient with a small amount of residual ethyl acetate. Upon intramuscular or subcutaneous injection of the composition, methadone, a partial opioid agonist or opioid antagonist is released in a controlled manner over an extended period of time. The composition finds use in the treatment of heroin addicts and alcoholics to reduce consumption of the abused substances. Of particular interest are the drugs buprenorphine, methadone and naltrexone.
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申请公布号 |
US7473431(B2) |
申请公布日期 |
2009.01.06 |
申请号 |
US20020324062 |
申请日期 |
2002.12.17 |
申请人 |
BROOKWOOD PHARMACEUTICALS, INC. |
发明人 |
TICE THOMAS R.;STAAS JAY K.;FERRELL TERESA M.;MARKLAND PETER |
分类号 |
A61F2/00;A61K9/14;A61K9/16;A61K9/50;A61K31/485;A61K47/10;A61K47/14;A61K47/32;A61K47/34;A61K47/38;A61P25/30;A61P25/32;A61P25/36 |
主分类号 |
A61F2/00 |
代理机构 |
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