| 摘要 |
The present invention relates to a colorimetric method for the detection of specific nucleic acids sequences, including mutations or single nucleotide polymorphisms within nucleic acid sequences, through the aggregation of nanoparticles functionalized with modified oligonucleotides, induced by an increase of the medium's ionic strength. Another aspect of the present invention relates with the development of a kit based on the method of the present invention, allowing for a quick and easy detection of specific nucleic acids sequences, including mutations or single nucleotide polymorphisms within nucleic acid sequences. |
| 申请人 |
STAB VIDA, INVESTIGACAO E SERVICOS EM CIENCIAS BIOLOGICAS, LDA;UNIVERSIDADE NOVA DE LISBOA;RAMOS FRANCO TAVARES, JOSE RICARDO;RIBEIRO VIANA BAPTISTA, PEDRO MIGUEL;REIMAO PINTO DE FRANCA DORIA, GONCALO MARIA;DE LEAO FLORES, ALCINO ORFEU |
发明人 |
RAMOS FRANCO TAVARES, JOSE RICARDO;RIBEIRO VIANA BAPTISTA, PEDRO MIGUEL;REIMAO PINTO DE FRANCA DORIA, GONCALO MARIA;DE LEAO FLORES, ALCINO ORFEU |
