发明名称 |
A method for detecting peptide comprising a cross-<beta> structure |
摘要 |
The invention relates to the detection and/or removal of conformationally altered proteins and/or molecules comprising a cross-&bgr; structure from a pharmaceutical composition. Disclosed is that unwanted and/or toxic side effects of pharmaceuticals are caused by proteins present in the pharmaceutical and adopting a cross-&bgr; structure conformation. Further disclosed is a method for detecting a protein in a pharmaceutical composition, the method comprising: contacting the pharmaceutical composition or any of its constituents comprising a protein with at least one cross-&bgr; structure-binding compound resulting in a bound protein and/or peptide comprising a cross-&bgr; structure and; detecting whether bound protein and/or peptide comprising a cross-&bgr; structure are present in the pharmaceutical composition or any of its constituents comprising a protein. Further described are methods for removing cross-&bgr; structures from a pharmaceutical composition and controlling the manufacture of a pharmaceutical composition. |
申请公布号 |
ZA200800521(B) |
申请公布日期 |
2008.12.31 |
申请号 |
ZA20080000521 |
申请日期 |
2008.01.17 |
申请人 |
CROSSBETA BIOSCIENCES B.V. |
发明人 |
GEBBINK, MARTIJN FRANS BEN GERARD;BOUMA, BAREND |
分类号 |
A61K;C07K;G01N |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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