| 摘要 |
<p>The invention relates to a pharmaceutical composition and oral dosage forms comprising a bisphosphonate in combination with an enhancer to enhance intestinal deliver of the bisphosphonate to the underlying circulation. Preferably, the enhancer is a medium chain fatty acid or a medium chain fatty acid derivative having a carbon chain length of from 6 to 20 carbon atoms, and the solid oral dosage form is a controlled release dosage form such as a delayed release dosage form. The composition is administered to the patient before bedtime, within six hours after consuming food, medications or beverages other than water or daily, weekly or monthly at specific dosage regimens.</p> |
