METHOD FOR DETERMINATION OF A POTENTIAL MUTATION

摘要

The invention is directed to a method for non-invasive determination of the potential presence of one or more loss-of-function mutation(s) in the gene encoding for filaggrin. The method of the invention comprises (i) obtaining a vibrational spectrum from the stratum corneum of the individual; (ii) determining the local natural moisturising factor content from the vibrational spectrum; (iii) optionally repeating steps (i) and (ii); and (iv) comparing the local natural moisturising factor content of the individual to a reference value, wherein said stratum corneum is stratum corneum of a location of the body of said individual at which said one or more loss-of-function mutation(s) in the gene encoding for filaggrin has a stronger influence on the natural moisturising factor concentration than other factors influencing the natural moisturising factor concentration.