METHOD OF REDUCING THE SEVERITY OF HOST VS. GRAFT REACTION BY DOWN-REGULATING HSP60 AUTOIMMUNITY

摘要

A method for reducing the severity of host vs. graft reaction (HVGR) by the transplant recipient of donor organ or tissue by the transplant recipient and is based on the discovery that hsp60 autoimmunity c an function as an accelerator of foreign immunity and the down-regulation of hsp60 autoimmunity suppresses or prevents the graft rejection reaction. Administration of any composition which causes the down-regulation of hsp60 autoimmunity, such as hsp60 or peptide p277 in a tolerogenic carrier or a biologically active carrier capable of mediating a TH1~TH2 shift, will thus reduce the severity of HVGR.