The present disclosure relates to methods of identifying target nucleic acids by using coded molecules and its analysis by translocation through a nanopore. Generally, coded molecules are subject to a target polynucleotide dependent modification. The modified coded molecule is detected by isolating the modified coded molecules from the unmodified coded molecules prior to analysis through the nanopore or by detecting a change in the signal pattern of the coded molecule when analyzed through the nanopore.
申请公布号
WO2007117832(A3)
申请公布日期
2008.12.18
申请号
WO2007US63828
申请日期
2007.03.12
申请人
APPLERA CORPORATION;SHARAF, MUHAMMAD A.;WOUDENBERG, TIMOTHY M.;MULLAH, KHAIRUZZAMAN BASHAR
发明人
SHARAF, MUHAMMAD A.;WOUDENBERG, TIMOTHY M.;MULLAH, KHAIRUZZAMAN BASHAR