NEW BIS-PLATINUM COMPLEX WITH POLYMETHYLENE DERIVATIVE AS LIGAND HAVING ANTITUMOR ACTIVITY

摘要

PROBLEM TO BE SOLVED: To provide a method for producing an intermediate for a bis-platinum (II) complex.

SOLUTION: The method for producing a polymethylene derivative of chemical formula (III) comprises a step of protecting the nitrogen atom of an ω-amino acid with a tert-butyloxycarbonyl group and treating with an inorganic acid to form the first intermediate which is not a chlorinated acid, a step of reacting the first intermediate with a second intermediate formed by a diamine having one amino group protected with about 0.3-0.5 mol of a tert-butyloxycarbonyl group based on 1 mol of the diamine to form the second intermediate, and a step of removing the tert-butyloxycarbonyl group from the second intermediate.

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