TREATMENT OF PATIENTS WITH AUTOANTIBODY POSITIVE DISEASE
摘要
The present invention relates to methods and compositions for use in treatment of patients with autoantibody positive disease. In a specific embodiment, the present invention relates to a method of treating a patient that has an ANA titer of 1:80 or greater and/or greater than or equal to 30 IU/ml of anti-dsDNA antibodies in his/her blood plasma or serum comprising administering a therapeutically effective amount of an immunomodulatory agent, such as an antagonist of Neutrokine-alpha. Additionally provided is a method of reducing the frequency and/or quantity of corticosteroid administration to patients. In preferred embodiments, the patient has systemic lupus erythematosus. Methods for determining if a lupus patient is responding to medical treatment are also provided.
申请公布号
WO2007142667(A3)
申请公布日期
2008.12.18
申请号
WO2006US38756
申请日期
2006.10.05
申请人
HUMAN GENOME SCIENCES, INC.;CHEVRIER, MARC;FRIEMUTH, WILLIAM;ZHONG, ZHENSHAO;ODENHEIMER, DANIEL;PERKINS, MELISSA, D.
发明人
CHEVRIER, MARC;FRIEMUTH, WILLIAM;ZHONG, ZHENSHAO;ODENHEIMER, DANIEL;PERKINS, MELISSA, D.