The invention provides a multiple layer filter media for removal of particles from a fluid stream. The multiple layer filter media may include a depth filtration layer, a membrane filtration layer and a support layer. Additional layers may be present. The membrane filtration layer may comprise expanded polytetrafluoroethylene (ePTFE). The various layers of the multiple layer filter media may be bonded together through a plurality of point bonds. The point bonding process may include simultaneously bonding multiple layers of the multiple layer filter media together in a single operation. The point bonds may be created using ultrasonic bonding.