| 摘要 |
<p>Methylmethioninesulfonium compounds of the formula <IMAGE> wherein X(-) represents an anion; R1 represents a hydrogen atom or an acyl group of the formula -COR3 in which R3 represents an alkyl group with 1 to 20 carbon atoms, the group -CH2)2 COOH or the group <IMAGE> in which Z represents a direct bond or a methylene or vinylene linkage, Y represents C or N, R4 represents a member selected from the class consisting of a hydrogen atom, lower alkyl groups, lower alkoxy groups, di-lower-alkylamino groups and a sulfamoyl group, n is a number of 1 to 3, and two or more R4 groups may be identical or different; and R2 represents the group -COOR5 in which R5 represents a hydrogen atom, an alkyl group with 1 to 5 carbon atoms or a metal- or metal complex-forming moiety, or the group <IMAGE> in which R6 groups may be identical or different, and each represent a hydrogen atom or an alkyl group with 1 to 5 carbon atoms, with the proviso that when R1 represents a hydrogen atom, R2 is not -COOH; when R1 represents a hydrogen atom and R2 represents -CONH2, X(-) is not Cl(-); and when R1 is -COCH3 and R2 is -COOCH3, X(-) is not I(-). The compounds can be easily prepared from methionine as a starting material by a combination of known unit reactions such as methylsulfonium-forming reaction, acylation, amidation, esterification and metal salt-forming reaction. These compounds are especially useful for treating ulcers.</p> |
