摘要 |
A compound of the formula (I): <IMAGE> (I) wherein A is a monocyclic or polycyclic heteroaromatic ring containing at least one nitrogen atom as a hetero atom, which may be unsubstituted or substituted with one or more substituents; R is a phenyl group which can be unsubstituted or substituted or a thienyl group; T is (1) a -CH2-S-Het group, where Het is a tetrazolopyridazine ring, a triazolopyridazine ring, or a triazolopyridine ring, (2) a <IMAGE> group wherein R1 and R2, which may be the same or different, each is a hydrogen atom or a (C1-C4)alkyl group, (3) a -CH2N3 group or (4) is -CH2S-D group in which D is a group selected from the group consisting of <IMAGE> <IMAGE> +TR <IMAGE> where m and n each is 0 to 3: with the proviso that (a) when the HO-A- moiety is a <IMAGE> group where b represents the non-metallic atoms necessary to complete a pyridine ring, a pyrimidine ring or a pyrazole ring, each of which may be unsubstituted or substituted, then T is the -CH2SD group wherein D is as defined above, and (b) when T is the -CH2N3 group, then R is a substituted phenyl group and the non-toxic, pharmaceutically acceptable salts thereof, processes for preparing the same, and anti-microbial compositions containing the same.
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