| 摘要 |
PURPOSE:To obtain an immunoglobulin, having high stability and water solubility and containing inactivated contaminating viruses, by heating a chemically unmodified immunoglobulin for intravenous injection in fear of viral contamination in a dry state, preferably in the presence of a stabilizer. CONSTITUTION:A chemically unmodified immunoglobulin for intravenous injection, e.g. IgG or IgA, derived from humans, horses or mice is heated in a dry state with <=3% moisture content, preferably in the presence of a stabilizer, e.g sugaralcohol, to inactivate contaminating viruses, e.g hepatitis viruses. The chemically unmodified immunoglobulin for intravenous injection is remarkably stabilized by the above-mentioned method and the chemically unmodified immunoglobulin subjected to dry heat treatment under the above-mentioned condition has improved solubility in water and solution property. The heat treatment is normally carried out at 30-100 deg.C for 10min-200hr and the stabilizer is used in a corresponding amount to give 0.8-5wt/vol% concentration based on a 1wt/vol% solution of the chemically unmodified immunoglobulin for intravenous injection.
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