ANTITHROMBOGENIC POLYURETHANE SURFACE

摘要

There is disclosed an antithrombogenic coating bonded to a support substrate, the coating comprising a polyurethane-urea which is bonded to said support and an antithrombogenic agent covalently bonded to said polyurethane-urea, the antithrombogenic agent and the polyurethane-urea being covalently bonded through the reaction of the amine groups of an amine rich polyurethane-urea which is bonded to the support substrate with the free aldehyde groups of a thrombogenic agent having free aldehyde groups. …A method of imparting antithrombogenic activity to a support substrate is also disclosed.