发明名称 |
N,N'-Bis(alkoxy-alkyl)-pyridine-2,4-dicarboxylic acid amides, process for their preparation as well as their use. |
摘要 |
N,N'-bis(alkoxyalkyl)pyridine-2,4-dicarboxylic acid diamides of the formula I <IMAGE> where R<1> is linear or branched C1-C4-alkanediyl, R<2> is unbranched C1-C4-alkyl or hydrogen and n is 1 or 2 and R<1'>, R<2'> and n' have the same meanings as R<1>, R<2> and n, where R<1> and R<1'>, R<2> and R<2'>, and n and n' are identical or different, and their physiologically acceptable salts with the exception of N,N'-bis(2-methoxyethyl)pyridine-2,4-dicarboxylic acid diamide and N,N'-bis(2-hydroxyethyl)pyridine-2,4-dicarboxylic acid diamide. The compounds of the formula I inhibit prolin hydroxylase and lysin hydroxylase and are suitable as fibrosuppressants and immunosuppressants.
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申请公布号 |
EP0409119(A1) |
申请公布日期 |
1991.01.23 |
申请号 |
EP19900113528 |
申请日期 |
1990.07.14 |
申请人 |
HOECHST AKTIENGESELLSCHAFT |
发明人 |
BAADER, EKKEHARD, DR.;BICKEL, MARTIN, DR.;GUENZLER-PUKALL, VOLKMAR, DR. |
分类号 |
C07D213/81;A61K31/44;A61K31/455;A61P37/06;C07D213/82 |
主分类号 |
C07D213/81 |
代理机构 |
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