SYNTHESIS AND OPTICAL RESOLUTION OF THE TAXOL SIDE CHAIN AND RELATED COMPOUNDS
摘要
This invention relates to a method for the production of a substantially optically pure taxane side chain comprising the steps of synthesizing a racemic mixture of enantiomers of the taxane side chain that is capable of exhibiting conglomerate behavior and resolving the substantially optically pure enantiomers by direct crystallization methods. This invention also relates to the semisynthesis of taxanes such as taxol through coupling the substantially optically pure taxane side chain to a taxane ring nucleus.
申请公布号
WO9310076(A1)
申请公布日期
1993.05.27
申请号
WO1992US09911
申请日期
1992.11.19
申请人
THE UNIVERSITY OF MISSISSIPPI
发明人
PETERSON, JOHN, R.;ZJAWIONY, JORDAN, K.;ROGERS, ROBIN, D.