1,2,4-OXADIAZOLE BENZOIC ACID COMPOUNDS, PHARMACEUTICAL COMPOSITION (VARIANTS) AND THEIR USE FOR TREATING A DISEASE AMELIORATED BY MODULATION OF PREMATURE TRANSLATION TERMINATION OR NONSENSE-MEDIATED MRNA DECAY

摘要

Novel 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising an 1,2,4-oxadiazole benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.