OPTIMIZED Fc-VERSIONS THAT HAVE ALTERED BINDING TO FcgammaR AND METHODS FOR THEIR PRODUCTION

摘要

FIELD: chemistry, pharmacology. ^ SUBSTANCE: invention relates to optimized Fc-versions of initial Fc polypeptide, showing altered binding to FcgammaR - the Fc-receptor, preferably human. Optimized Fc- versions include at least one amino acid modification in Fc-site of initial Fc polypeptide. Binding alteration mentioned represents increase in affinity of Fc-variant to FcgammaR. Invention relates to pharmaceutical composition, showing altered binding to FcgammaR based on optimised Fc- version and pharmaceutically acceptable carrier. Invention relates also to mammal treatment for antibody-dependent disorders method with optimised Fc. Invention provides Fc-versions that are optimised toward a number of important therapeutic properties. ^ EFFECT: increased efficiency of composition application. ^ 43 cl, 59 dwg, 70 tbl, 15 ex