| 发明名称 |
Heterobicyclic metalloprotease inhibitors |
| 摘要 |
The present invention relates generally to azabicyclic containing pharmaceutical agents, and in particular, to azabicyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of azabicyclic MMP-3, MMP-8 and/or MMP-13 inhibiting compounds, which exhibit an increased potency and selectivity in relation to currently known MMP-13, MMP-8 and MMP-3 inhibitors.
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| 申请公布号 |
US2008261968(A1) |
申请公布日期 |
2008.10.23 |
| 申请号 |
US20070986626 |
申请日期 |
2007.11.20 |
| 申请人 |
GEGE CHRISTIAN;SCHNEIDER MATTHIAS;CHEVRIER CARINE;DENG HONGBO;SUCHOLEIKI IRVING;GALLAGHER BRIAN M;BOSIES MICHAEL;STEENECK CHRISTOPH;WU XINYUAN;HOCHGURTEL MATTHIAS;NOLTE BERT;TAVERAS ARTHUR |
发明人 |
GEGE CHRISTIAN;SCHNEIDER MATTHIAS;CHEVRIER CARINE;DENG HONGBO;SUCHOLEIKI IRVING;GALLAGHER BRIAN M.;BOSIES MICHAEL;STEENECK CHRISTOPH;WU XINYUAN;HOCHGURTEL MATTHIAS;NOLTE BERT;TAVERAS ARTHUR |
| 分类号 |
A61K31/5375;A61K31/517;A61K31/519;A61K31/52;A61P19/02;C07D239/72;C07D413/02;C07D473/00;C07D495/04 |
主分类号 |
A61K31/5375 |
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