发明名称 |
CHIMERIC HCN CHANNELS. |
摘要 |
<p>This invention provides a chimeric hyperpolarization-activated, cyclic nucleotide-gated (HCN) polypeptide comprising portions of more than one type of HCN channel. The invention also provides methods of treating a subject afflicted with a cardiac rhythm disorder comprising expression of the chimeric HCN polypeptide in a selected region of the heart so as to induce a pacemaker current in the heart and thereby treat the subject.</p> |
申请公布号 |
MX2008003296(A) |
申请公布日期 |
2008.10.23 |
申请号 |
MX20080003296 |
申请日期 |
2006.09.11 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK |
发明人 |
MICHAEL R. ROSEN;PETER R. BRINK;RICHARD B. ROBINSON;IRA S. COHEN |
分类号 |
A61K31/713;A61K35/12;A61K38/17;C07K14/705;C12N5/10;C12N15/12;C12N15/63;C12P21/02 |
主分类号 |
A61K31/713 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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