发明名称 |
Immunostimulating Agents |
摘要 |
Disclosed is a new type of immunostimulating agent including an immunostimulating oligonucleotide complexed with a carrier which is safe and has a high transfection effect. The carrier complexed with the immunostimulating oligonucleotide to form the immunostimulating agent is a polysaccharide having beta-1,3-bonds (preferably beta-1,3-glucan such as schizophyllan). A preferred example of the immunostimulating oligonucleotide is one containing an unmethylated CpG motif. The polysaccharide for use is preferably modified with nucleic acid-binding functional group and/or cell membrane-affinitive functional group.
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申请公布号 |
US2008262210(A1) |
申请公布日期 |
2008.10.23 |
申请号 |
US20040557108 |
申请日期 |
2004.05.13 |
申请人 |
MITSUI SUGAR CO., LTD.;JAPAN SCIENCE AND TECHNOLOGY AGENCY |
发明人 |
MIZU MASAMI;SHINKAI SEIJI;SAKURAI KAZUO;KOUMOTO KAZUYA;NUMATA MUNENORI;MATSUMOTO TAKAHIRO |
分类号 |
C07H21/00;A61K9/00;A61K31/7125;A61K47/36;A61P37/04;C08B37/00 |
主分类号 |
C07H21/00 |
代理机构 |
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地址 |
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