DIAGNOSIS AND TREATMENT OF DISEASES CAUSED BY MISFOLDED PROTEINS

摘要

In certain aspects, the disclosure relates to methods and compositions fo r diagnosing and treating diseases caused by misfolded proteins that compris e monitoring ANKRD 16 expression and altering the activity of ANKRD 16 prote in. In certain embodiments, the diseases are neurodegenerative diseases. In certain embodiments, the diseases are proteopathies. In certain embodiments, the disease is reduced fertility. Methods for identifying agents that prote ct against cell death are also provided.