PROCESS OF ENANTIOMERIC RESOLUTION OF D,L-( + )-THREO-METHYLPHENIDATE
摘要
<p>A process for preparing the d-threo isomer of methylphenidate hydrochloride which includes (i) resolving a racemic mixture of racemic threo-methylphenidate hydrochloride with a less than stoichiometric amount of tertiary amine base to obtain a methylphenidate - chiral acid salt, (ii) basifying the methylphenidate - chiral acid salt to obtain methylphenidate free base, and (iii) converting the methylphenidate free base into d-threo-methylphenidate hydrochloride</p>
申请公布号
WO2008125914(A2)
申请公布日期
2008.10.23
申请号
WO2007IB04583
申请日期
2007.12.19
申请人
ARCHIMICA, INC.;KALININ, ALEXEI;QIU, GUOFANG;MARREN, THOMAS J.;ALDRED, JR., JAMES E.;JI, YU
发明人
KALININ, ALEXEI;QIU, GUOFANG;MARREN, THOMAS J.;ALDRED, JR., JAMES E.;JI, YU