| 发明名称 |
MATERIAL FOR PREPARING MODIFIED ANTIBODY VARIABLE DOMAIN AND THERAPEUTIC USE THEREOF |
| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a variable domain having a modified residue suitable for administering to heterogeneous animals. <P>SOLUTION: The modified variable antibody domain which is modified to have a substituted amino acid residue bindable to an antigen without diminishing the native affinity of the antibody variable domain for the antigen, while reducing its immunogenicity with respect to the heterogeneous species is provided. <P>COPYRIGHT: (C)2009,JPO&INPIT |
| 申请公布号 |
JP2008253267(A) |
申请公布日期 |
2008.10.23 |
| 申请号 |
JP20080113288 |
申请日期 |
2008.04.24 |
| 申请人 |
XOMA TECHNOLOGY LTD |
发明人 |
STUDNICKA GARY M;LITTLE ROGER G II;FISHWILD DIANNE M;KOHN FRED R |
| 分类号 |
C12N15/09;A61K9/08;A61K9/12;A61K9/19;A61K9/50;A61K31/519;A61K31/52;A61K31/573;A61K31/675;A61K38/00;A61K39/395;A61K45/00;A61P1/04;A61P1/16;A61P3/10;A61P5/14;A61P7/06;A61P9/04;A61P17/06;A61P17/12;A61P19/02;A61P21/04;A61P25/00;A61P27/02;A61P29/00;A61P31/04;A61P37/02;A61P37/06;A61P43/00;C07K1/107;C07K14/00;C07K16/00;C07K16/18;C07K16/28;C07K16/46;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/13;C12P21/08;C12R1/91;G01N33/48;G01N33/50;G01N33/53;G01N33/68;G06F19/16;G06F19/18;G06F19/22 |
主分类号 |
C12N15/09 |
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