Means and method for assessing the risk of a cardiac intervention in patients suffering from a stable coronary heart disease based on GDF-15

摘要

The present invention relates to a method for diagnosing whether a percutaneous cardiac intervention (PCI) in a subject suffering from a stable coronary heart disease was successful, said method comprising determining the amount of GDF-15 in a first sample of the said subject which has been obtained after PCI and comparing the determined amount of GDF-15 with a reference amount of GDF-15 which is determined in a second sample of the said subject suffering from a stable coronary heart disease obtained prior to PCI, whereby it is diagnosed whether PCI was successful. Further, the present invention relates to the use of means for determining the amount of GDF-15 and, preferably, a natriuretic peptide and/or a cardiac Troponin for the preparation of a diagnostic composition for diagnosing whether a percutaneous cardiac intervention (PCT) in a subject suffering from a stable coronary heart disease was successful. The present invention also encompasses a device and a kit adopted for diagnosing whether a percutaneous cardiac intervention (PCI) in a subject suffering from a stable coronary heart disease was successful.