发明名称 |
ITRACONAZOLE-CONTAINING SOLID DISPERSION AND PROCESS FOR THE PREPARATION THEREOF |
摘要 |
An itraconazole-containing solid dispersion is provided to improve dissolution rate, prevent gelation and prepare high amount of itraconazole-containing formulation by modifying the surface of itraconazole-containing solid dispersion with a specific disintegrant. An itraconazole-containing solid dispersion contains 100 parts by weight of itraconazole, 50-150 parts by weight of hydrophilic polymer, 20-50 parts by weight of acidifying agent and is coated by 30-60 parts by weight of disintegrant selected from sodium starch glycolate, carboxy methyl cellulose calcium, cross-linked carboxy methyl cellulose, cross-linked polyvinyl pyrrolidone and crosscamelose sodium. A pharmaceutical composition contains the itraconazole-containing solid dispersion and pharmaceutically acceptable carriers. Further, a form of the pharmaceutical composition is tablets.
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申请公布号 |
KR20080090057(A) |
申请公布日期 |
2008.10.08 |
申请号 |
KR20070033033 |
申请日期 |
2007.04.04 |
申请人 |
DAEWOONG PHARMACEUTICAL CO., LTD. |
发明人 |
CHANG, HEE CHUL;SHIN, HYOUNG GOO;LEE, MIN SUK;KANG, BOK KI |
分类号 |
A61K9/10;A61K31/496 |
主分类号 |
A61K9/10 |
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