Quinoline intermediates of receptor tyrosine kinase inhibitors and the synthesis thereof

摘要

This invention is directed to methods of preparing 4-substituted quinoline compounds as intermediates in the manufacture of receptor tyrosine kinase inhibitors and intermediate compounds used in the methods thereof, wherein the 4-substituted quinoline compound has the following general formula (I): wherein substitutions at LG'', PG, A, G, R₁ and R₄ are set forth in the specification.