发明名称 |
Recombinant Newcastle Disease Virus |
摘要 |
The goal of the invention is to increase the therapeutical activity of oncolytic NDV. This issue is solved by a Newcastle Disease Virus comprising a recombinant nucleic acid, wherein the nucleic acid codes for a binding protein that has a therapeutic activity when expressed by the virus-infected tumor cell. Binding proteins belong to the following group: A natural ligand or a genetically modified ligand, a recombinant soluble domain of a natural receptor or a modified version of it, a peptide-ligand, an antibody molecule and derivatives thereof or antibody-like molecules like ankyrin repeat molecules or derivatives thereof.
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申请公布号 |
US2008206201(A1) |
申请公布日期 |
2008.08.28 |
申请号 |
US20050667563 |
申请日期 |
2005.11.10 |
申请人 |
BEIER RUDOLF;PUEHLER FLORIAN;BOSSLET KLAUS;WILLUDA JOERG HANS |
发明人 |
BEIER RUDOLF;PUEHLER FLORIAN;BOSSLET KLAUS;WILLUDA JOERG HANS |
分类号 |
A61K35/76;A61P35/00;C07H21/04;C12N5/06;C12N7/00;C12N7/01 |
主分类号 |
A61K35/76 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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