发明名称 |
Method for the production of cladribine |
摘要 |
A method for producing cladribine (2-chloro-2'-deoxyadenosine) comprising the steps of:
a) reaction of 2-deoxyuridine with 2-chloroadenine, in the presence of uridine phosphorylase (UPase) and purine nucleoside phosphorylase (PNPase) in an aqueous reaction medium possibly containing up to 40% v/v of an aprotic dipolar solvent, to obtain cladribine dissolved in said reaction medium;
b) isolation of the cladribine by precipitation by means of concentration and alkalinisation of the reaction medium up to pH 11.5-12.5.
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申请公布号 |
EP1932918(A1) |
申请公布日期 |
2008.06.18 |
申请号 |
EP20060026046 |
申请日期 |
2006.12.15 |
申请人 |
EXPLORA LABORATORIES SA |
发明人 |
ZUFFI, GABRIELE;MONCIARDINI, SIMONE |
分类号 |
C12P19/40;C07D473/40;C12N9/10 |
主分类号 |
C12P19/40 |
代理机构 |
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主权项 |
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地址 |
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