TUMOR NECROSIS FACTOR (TNF) INHIBITORY PROTEIN AND ITS PURIFICATION

摘要

Tumor Necrosis Factor (TNF) Inhibitory Protein and salts, functional derivatives and active fractions thereof are disclosed, having the ability to inhibit the binding of TNF to its receptors and the cytotoxic effect of TNF and which can be used against the deleterious effects of TNF. Also disclosed is a process for the purification of said TNF Inhibitory Protein and to the substantially purified protein, its cloning and its production by recombinant DNA techniques. Pharmaceutical compositions comprising such a protein, or salts, functional derivatives and active fractions thereof, for protecting against the deleterious effects of TNF are disclosed as well.