| 摘要 |
Novel esters of nonsteroidal anti-inflammatory drugs with oligomers of 3-hydroxybutyric acid of the invention possess the general formula 1, where n from 2 to 35, and R is a radical of a non-steroidal anti-inflammatory drug selected from the group consisting of ibuprofen, ketoprofen, fenoprofen, naproxen, diclofenac, indomethacine, sulindac, tolmetin or salicylic acid. The method of preparation of compounds of the formula 1 consists in converting nonsteroidal anti-inflammatory drugs into a monosodium or monopotassium salts in the presence of a strongly polar solvent, preferably dimethyl sulfoxide (DMSO) or dimethylformamide (DMF), and in subjecting the obtained salts to the reaction with ²-butyrolactone to open the lactone ring and to polymerize the lactone. The esters of the invention contain a nonsteroidal anti-inflammatory drugs bonded by means of an ester bond with oligomers of 3-hydroxybutyric acid including 2-35 mers as constituting biocompatible polymer carriers. |
