USE OF CR1-BINDING MOLECULES IN CLEARANCE AND INDUCTION OF IMMUNE RESPONSES

摘要

The present invention provides methods and compositions related to the discovery of molecules capable of both inducing an immune response to an antigen in a mammal and also effectiing clearance of the antigen, with such molecules comprising a first moiety comprising an antigen binding portion which binds specifically to complement receptor 1 (CR1) and does not substantially bind to complement receptor 2 (CR2), linked to a second moiety which comprises the antigen or binds to the antigen. Methods of producing su ch molecules and their therapeutic and/or prophylactic uses are also featured.< /SDOAB>