发明名称 |
GRIFFITHSIN, GLYCOSYLATION-RESISTANT GRIFFITHSIN, AND RELATED CONJUGATES, COMPOSITIONS, NUCLEIC ACIDS, VECTORS, HOST CELLS, METHODS OF PRODUCTION AND METHODS OF USE |
摘要 |
An isolated and purified nucleic acid molecule that encodes a polypeptide comprising at least eight contiguous amino acids of SEQ ID NO: 3, wherein the at least eight contiguous amino acids have anti-viral activity, as well as an isolated and purified nucleic acid molecule that encodes a polypeptide comprising at least eight contiguous amino acids of SEQ ID NO: 3, wherein the at least eight contiguous amino acids have anti-viral activity, and, when the at least eight contiguous amino acids comprise amino acids 1-121 of SEQ ID NO: 3, the at least eight contiguous amino acids have been rendered glycosylation-resistant, a vector comprising such an isolated and purified nucleic acid molecule, a host cell comprising the nucleic acid molecule, optionally in the form of a vector, a method of producing an anti-viral polypeptide or conjugate thereof, the anti-viral polypeptide itself, a conjugate or fusion protein comprising the anti-viral polypeptide, and compositions comprising an effective amount of the anti-viral polypeptide or conjugate or fusion protein thereof. Further provided are methods of inhibiting prophylactically or therapeutically a viral infection of a host. |
申请公布号 |
WO2005118627(A3) |
申请公布日期 |
2006.04.27 |
申请号 |
WO2005US18778 |
申请日期 |
2005.05.27 |
申请人 |
UMAN SERVICES ENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HGOVERNMENT OF THE UNITED STATES OF AMERICA, REPRES;BOYD, MICHAEL R.;MORI, TOSHIYUKI;O'KEEFE, BARRY |
发明人 |
BOYD, MICHAEL R.;MORI, TOSHIYUKI;O'KEEFE, BARRY |
分类号 |
A61K38/17;A61K47/48;C07K14/405;C07K16/14 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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