发明名称 |
Chimeric peptides as immunogens, antibodies thereto, and methods for immunization using chimeric peptides or antibodies |
摘要 |
The invention provides a chimeric peptide or mixture of chimeric peptides that can be formulated as an immunizing composition and used in a method for immunization of a mammal against an internal peptide cleavage product derived from a precursor or mature protein, for which the peptide cleavage product and the precursor or mature protein are self molecules. The chimeric peptide or peptides have an end-specific B cell epitope from a naturally-occurring internal peptide cleavage product of a precursor or mature protein, as a free N- or C-terminus, fused with or without spacer residues to a T helper cell epitope derived from a living source different from that of the internal peptide cleavage product.
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申请公布号 |
US2006088548(A1) |
申请公布日期 |
2006.04.27 |
申请号 |
US20000731899 |
申请日期 |
2000.12.08 |
申请人 |
CHAIN BENJAMIN |
发明人 |
CHAIN BENJAMIN |
分类号 |
C12P21/08;C12Q1/68;A61K38/00;A61K39/00;A61K39/39;A61K39/395;A61P25/28;C07H21/04;C07K14/47;C07K16/18;C07K19/00;C12N15/62;C12P21/04 |
主分类号 |
C12P21/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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