发明名称 |
GENERATION AND DIFFERENTIATION OF ADULT STEM CELL LINES |
摘要 |
<p>The present invention teaches a new method of stem cell generation involving the establishment of a mesenchymal cell culture, induction of epithelial marker expression and isolation and cloning of the cells expressing epithelial markers and expansion of these cell lines. Further processes are described for a two-step method to induce the differentiation of terminally differentiated cell types such as insulin-producing beta cells of the human pancreas gland. The invention indicates that mesenchymal to epithelial transition may be an important component in the development, renewal and regeneration of animal organ systems and provides a reliable method for <i</p> |
申请公布号 |
WO2006045105(A2) |
申请公布日期 |
2006.04.27 |
申请号 |
WO2005US38162 |
申请日期 |
2005.10.20 |
申请人 |
VITRO DIAGNOSTICS, INC.;MUSICK, JAMES, R. |
发明人 |
MUSICK, JAMES, R. |
分类号 |
A61K35/39;C12N5/071;C12N5/074 |
主分类号 |
A61K35/39 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|