COMPUESTOS DERIVADOS DE PIRIMIDIN-4,6-DIAMINA, INHIBIDORES DE LAS INTERACCIONES DE ATP-PROTEIN QUINASA; PROCEDIMIENTO DE PREPARACION; Y USO PARA EL TRATAMIENTO DE ENFERMEDADES TALES COMO ARTRITIS REUMATOIDE, DIABETES MELLITUS, ENFERMEDADES O TRASTORN

摘要

The present invention is directed to novel bicyclic pyrimidine compounds of Formula (I) or a form or composition thereof as inhibitors of ATP-protein kinase interactions, wherein substituents on each side of the iminomethyl double bond in Formula (I) may be in the E or Z configuration; and wherein R1, R2, R3 and R4 are as defined herein.