| 摘要 |
Process for the preperation of iron-sucrose complex, in which (a) an iron salt in aqueous solution is mixed with sucrose and an inorganic base, simultaneously or in any order, at a low temperature, in such a way that the reaction mixture has an acidity (pH) in the range 3<pH<12, and the reaction mixture is left at this acidity until all the iron salt has been converted to iron oxyhydroxide, wherein, when using an alkali metal hydroxide, the sucrose is always introduced at the beginning of the reaction or is added to the reaction mixture simultaneously with the alkali metal hydroxide; (b) the acidity of the reaction mixture is then raised to a value in the range 10<pH<12 and the reaction mixture is heated until the desired iron-sucrose complex has completely formed, and the iron-sucrose complex formed is then precipitated by mixing with a suitable water-miscible solvent, the iron-sucrose complex being purified by removal of the anions present and any excess base, before or after the precipitation; the iron-sucrose complex prepared in this way; its use for the preparation of drugs; and drugs containing such an iron-sucrose complex.
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