| 发明名称 |
METHOD FOR PREPARING 4-[17β-METHOXY-17α-METHOXYMETHYL-3-OXOESTR A-4,9-DIEN-11β-YL]BENZALDEHYDE (E)-OXIME (ASOPRISNIL). |
| 摘要 |
<p>The present invention relates to a method for the reliable and reproducible preparation of 4-[17β-methoxy-17α-methoxymethyl-3-oxoestra-4,9-dien-llβ- yl]benzaldehyde (E)-oxime (asoprisnil) on the pilot and manufacturing scale. Asoprisnil, which is prepared by this method, is distinguished by a very good physical stability and is therefore particularly suitable for the manufacture of solid pharmaceutical forms (tablets, coated tablets, etc.).</p> |
| 申请公布号 |
MX2008013336(A) |
申请公布日期 |
2008.10.31 |
| 申请号 |
MX20080013336 |
申请日期 |
2007.04.17 |
| 申请人 |
BAYER SCHERING PHARMA AKTIENGESELLSCHAFT |
发明人 |
DETLEF GRAWE;HAGEN GERECKE;SABINE GLIESING;PETER HOESEL;UWE MUELLER;THOMAS MICHEL;ROBERT EILERS;UWE KNABE;BERND ERHART;MICHAEL MOSEBACH;DAVID VOIGTLAENDER;ULF TILSTAM;JUERGEN JACKEN;KLAUS BAHL;ULF BOHLMANN;DIETER WEHMEIER;MICHAEL SANDER |
| 分类号 |
C07J41/00;A61K31/565;A61P5/36;C07J1/00;C07J21/00;C07J71/00 |
主分类号 |
C07J41/00 |
| 代理机构 |
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