COMPOUNDS FOR DIAGNOSING APOPTOSIS

摘要

The invention relates to a compound of the following general formula (I): Signal-Link-Peptide (I) in which Signal is a signal entity, Link is present or absent and is a chemical bond, and Peptide is a peptide including an apoptosis targeting peptide, the apoptosis targeting peptide being selected from the peptides of the following formula and the functional equivalents thereof: - X1-X2-X3-X4-X5-X6 (1) (SEQ ID No 1) in which X1 and X2 are each independently leucine or isoleucine, X3 and X4 are lysine, X5 is proline and X6 is phenlyalanine, advantageously the peptide L-I-K-K-P-F (SEQ ID No 11) and the functional equivalents thereof; - D-A-H-S-X7-S (2) (SEQ ID No 2) in which X7 is phenlyalanine or leucine; - P-G-D-L-X8-X9 (3) (SEQ ID No 3) in which X8 is serine or valine and X9 is threonine or arginine; - H-G-X10-L-S-X11 (4) (SEQ ID No 4) in which X10 is aspartic acid or histidine and X11 is threonine or isoleucine; - V-L-G-E-R-G (5) (SEQ ID No 5); and the pharmaceutically acceptable salts of said compounds.