发明名称 |
CD34 STEM CELL-RELATED METHODS AND COMPOSITIONS |
摘要 |
<p>The invention relates to CD34- stem cells for use as a medicament in the treatment of a subject afflicted with a gastrointestinal disorder. The invention relates to genetically modified CD34- stem cells, wherein each of the genetically modified CD34- stem cells contains an exogenous nucleic acid comprising (i) a region encoding a protein which enhances endothelial cell growth, which region is operably linked to (ii) an endothelium-specific promoter or promoter/enhancer combination, and to CD34- stem cells without genetic modification. In a preferred embodiment of the invention the cells and medical use thereof are characterised in that the introduction of the CD34- stem cells is not preceded, accompanied or followed by myeloablation.</p> |
申请公布号 |
CA2897188(A1) |
申请公布日期 |
2008.12.11 |
申请号 |
CA20082897188 |
申请日期 |
2008.05.20 |
申请人 |
APCETH GMBH & CO. KG |
发明人 |
HUSS, RALF;NELSON, PETER;RAGGI, MATTHIAS;STANGL, MANFRED |
分类号 |
A61K35/545;A61K35/28;A61P1/00 |
主分类号 |
A61K35/545 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|