发明名称 |
CD40-LIGAND ALS ADJUVANT FÜR RESPIRATORISCHES SYNCYTIALVIRUS-IMPFSTOFF |
摘要 |
The present invention provides methods and adjuvants for enhancing an immune response to RSV in a host, wherein the methods and adjuvants comprise a source of a CD40 binding protein. Preferably, the CD40 binding protein is CD40L and the source is a vector comprising a promoter operatively linked to a CD40L coding region. The enhanced immune response produced by the adjuvants and methods of the current invention includes both increased expression of Th1 cytokines and increased production of antibody. |
申请公布号 |
DE60136334(D1) |
申请公布日期 |
2008.12.11 |
申请号 |
DE2001636334 |
申请日期 |
2001.02.02 |
申请人 |
UNITED STATES GOVERNMENT AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES, CENTRE FOR DISEASE |
发明人 |
TRIPP, RALPH A.;ANDERSON, LARRY J.;BROWN, MICHAEL P. |
分类号 |
A61K39/155;A61K38/17;A61K39/39;A61P31/12;A61P37/04 |
主分类号 |
A61K39/155 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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