| 摘要 |
The composition, pharmaceutical form and processes in the present invention comprise a nucleus obtained by compression, having bioadherent property and gastric retention capacity, containing extended release, water-soluble anti-glucose-providing agent, also soluble in pH lower or equal to 5, having as controlled release regulating agent benzene-free polymerized polyacrylic acid or its derivatives. The nucleus may contain one or more acid-modulated coating layers with coadjuvant pharmacologically active agents, also having anti-glucose-providing effect, non-water-soluble and soluble in pH higher or equal to 5, immediate release, also comprising pharmaceutically acceptable excipients. The bioadherent nucleus allows controlled release of biguanides, preferably metformin and the coating layers allow sulphonylureas release, preferably glimepiride. The present invention allows isolated metformin release or combined release of two classes of drugs with different solubility and absorption conditions, and the volume of their final form is reduced.
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