发明名称 |
METHODS FOR INHIBITION OF LYMPHANGIOGENESIS AND TUMOR METASTASIS |
摘要 |
The present invention is directed to compositions and methods for inhibiting the development of new lymphatic vessels, and for inhibiting tumor cell dissemination through the lymphatics. In preferred embodiments, the present invention utilizes agents that inhibit the specific binding of integrin alpha4beta1 (a4ßl, VLA-4) to one or more of its ligands. The invention further relates to methods for screening test compounds for their ability to inhibit undesirable lymphangiogenesis and/or tumor metastasis. |
申请公布号 |
WO2007092471(A3) |
申请公布日期 |
2008.12.11 |
申请号 |
WO2007US03205 |
申请日期 |
2007.02.05 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;VARNER, JUDITH, A.;GARMY-SUSINI, BARBARA |
发明人 |
VARNER, JUDITH, A.;GARMY-SUSINI, BARBARA |
分类号 |
G01N33/53;A61K39/395;G01N33/567;G01N33/574 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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