| 摘要 |
<p>A substrate for use in crystallization has a base member, and an organic molecular film on a surface of the base member. The organic molecular film has non-affinity to a liquid, and the surface of the base member and the organic molecular film are covalently bound to each other. The substrate formed with the organic molecular film having non-affinity to the liquid on the surface of the base member is produced by contacting the surface of the base member having an active hydrogen atom or the surface of the base member to which the active hydrogen atom is introduced, with an organic molecule including a terminal-bonding functional group capable of covalently bonding to the surface of the base member at one end thereof, and a functional group showing non-affinity to the liquid at the other end thereof so as to covalently bond the terminal-bonding functional group of the organic molecule to the active hydrogen atom on the surface of the base member by reaction of the terminal-bonding functional group with the active hydrogen atom. The substrate enables to efficiently crystallize polymeric compounds including biomolecules such as proteins, nucleic acids, and sugars; and resins, as well as other organic compounds, and inorganic compounds.
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